Do you know what they say at the dermatology clinic if you tell them you're using retinol for your nasolabial folds? They say it will absolutely, positively never work. They told me it definitely won't get rid of existing wrinkles... So when I saw an ad for this, I asked the clinic manager what she thought about it, and she said this one actually makes sense and the principle behind it is right. So I thought about it and bought it. After about 3 weeks, I think I'm starting to see a difference. Best of all, the shadows from the indentation of my smile lines have lessened, which is such a relief. I rarely ever write reviews, but I'm leaving this because I think there are a lot of people out there who have been ripped off by wrinkle creams before.